By Ebrahim Ghafar-Zadeh

ISBN-10: 9048137268

ISBN-13: 9789048137268

Laboratory-on-Chip (LoC) is a multidisciplinary strategy towards the miniaturization, integration and automation of organic assays. A organic laboratory comprises a variety of items of apparatus used for acting various organic protocols. The engineering point of LoC layout is aiming to embed a lot of these parts in one chip for single-purpose purposes. LoC is a tender self-discipline that's anticipated to thus extend over the following couple of years, prompted by way of huge improvement of purposes within the mechanical, biochemical and electric engineering domain names. between a number of microelectronic units hired for LoC purposes, CMOS capacitive sensors have bought an important curiosity for numerous functions together with DNA detection, antibody-antigen attractiveness and micro organism development tracking. the most elements of CMOS capacitive biosensors together with sensing electrodes, bio-functionalized sensing layer, interface circuitries and microfluidic packaging are verbosely defined in chapters 2-6 after a quick creation on CMOS established LoCs in bankruptcy 1. CMOS Capacitive Sensors for Lab-on-Chip purposes is written in an easy pedagogical approach. It emphasises functional facets of totally built-in CMOS biosensors instead of mathematical calculations and theoretical info. by utilizing CMOS Capacitive Sensors for Lab-on-Chip Applications, the reader may have circuit layout methodologies, major very important organic capacitive interfaces and the necessary microfluidic fabrication strategies to create capacitive biosensor via commonplace CMOS process.

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Extra resources for CMOS Capacitive Sensors for Lab-on-Chip Applications: A Multidisciplinary Approach

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Ghafar-Zadeh and M. V. 1 CMOS based capacitive sensing LoC a b L3 CS CP L2 L1 d c f e E E M6 Via M5 Fig. 2 Unpassivated Electrodes Aluminum is still the major material used for electrical contacts and interconnections in CMOS circuits. g. 18 CMOS, Al/1%Si, Al with 1% Silicon) [64, 145]. Aluminum is not widely used for biosensing purposes as opposed to gold and platinum. Due to the oxidizing property of the biological and chemical analytes, if a durable conductive electrode is required, only noble metals like gold (Au) and platinum (Pt) can be used but not aluminum (Al).

The parasitic capacitances across the passivation layer (CP1), in-between the electrodes (CP2) and in between silicon substrate and electrodes (CP2) are also shown in this model. In fact, R and Cs can be obtained from the parallel combination of a large number of small elements (dCs, dR). 7 Illustration of (a) and (b) parasitics generated on top of a CMOS chip (dC and dR are the partial parasitic capacitance and resistance respectively), and (c) its equivalent circuit results in a current I = I1 + I2 +⋯+ In = nI1.

2 Unpassivated Electrodes Aluminum is still the major material used for electrical contacts and interconnections in CMOS circuits. g. 18 CMOS, Al/1%Si, Al with 1% Silicon) [64, 145]. Aluminum is not widely used for biosensing purposes as opposed to gold and platinum. Due to the oxidizing property of the biological and chemical analytes, if a durable conductive electrode is required, only noble metals like gold (Au) and platinum (Pt) can be used but not aluminum (Al). Despite this, a native Al2O3 layer (»10 nm) on the surface of Al is considered an advantage for biosensing applications [146].

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CMOS Capacitive Sensors for Lab-on-Chip Applications: A Multidisciplinary Approach by Ebrahim Ghafar-Zadeh


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