By Bernard L. Horecker, Earl R. Stadtman

ISBN-10: 0121528049

ISBN-13: 9780121528041

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The recovery of normal growth on ornithine as the sole source of nitrogen requires constitutivity only of ornithine transaminase, since the third enzyme of the pathway, pyrroline carboxylate dehydrogenase is already constitutive (39). The recovery of normal growth on arginine requires the constitutivity of both ornithine transaminase and arginase. Dominance or recessiveness expected for operator and for repressor mutations, respectively, can be analyzed directly in diploids homozygotic for argRl and ar^RII, resulting from a cross with the strain 120c which is identical with the parent strain of the mutants, 7000a, except for the mating type.

And Krebs, E. , / . Biol. Chem. 216, 121 (1955). 13. Gerhart, J. C , and Pardee, A. , J. Biol. Chem. 237, 891 (1962). 14. , Proc. Nat. Acad. Sci. S. 56, 1891 (1966). 15. Grillo, M. , Italian J. Biochem. 2 8 , 133 (1969). 16. , and Wiame, J. , Arch. Int. Physiol. Biochem. 78, 166 (1969). 38 J. M. WIAME 17. Hermann, R. , Lou, H. , and White, C. , Biochim. Biophys. Ada 121, 79 (1966). 17a. , and Wiame, J. , unpublished. 17b. , and Wiame, J. , in preparation. 18. , Advan. Enzymol. 32, 297 (1969).

Arch. Int. Physiol. Biochem 79, 204 (1971). 33. , and Wiame, J. , Biochim. Biophys. Ada 139, 98 (1967). 34. , Wiame, J. , Eur. J. Biochem. 12, 40 (1970). 35. Salas, M. , Biochem. Biophys. Res. Commun. 31, 461 (1968). 36. , Cold Spring Harbor Symp. Quant. Biol. 31, 345 (1966). 37. Stachow, C. , and Sanwal, B. , Biochim. Biophys. Acta 139, 294 (1967). 38. , and Wiame, J. , Biochim. Biophys. Ada 139, 91 (1967). 39. , Thesis, University of Brussels (1970). 40. , Wiame, J. , Arch. Int. Physiol Biochem.

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Current topics in cellular regulation Vol. 4 by Bernard L. Horecker, Earl R. Stadtman


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