By Paul Flecknell, Avril Waterman-Pearson BVSc PhD FRCVS DVA DiplECVA
Ultimately a very sturdy useful booklet on the way to deal with ache. It sincerely summarises the proof that animals believe soreness after which - this the simplest bit - turns the technology into genuine support for front-line working towards vets.
A must-have for all vets in all places
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Extra info for Pain Management in Animals
There is much controversy over the selectivity of these compounds that are currently licensed, however, with cont1icting data being obtained depending on the test systems used for assessing COX-l and COX-2 selectivity, and also whether these assays are PHARMACOLOGY OF ANALGESIC DRUGS Chapter 3 carried out in vitro, ex vivo or in vivo. In addition, drugs may appear selective for one enzyme over the other while not being highly potent. Currently there are no COX-2 specific drugs licensed for use in veterinary medicine.
It is an enantiornerically pure (S-enantiomer) amide local anaesthetic drug which has greater selectivity for nerve fibres responsible for transmission of pain (Ao and C fibres) than for those that control motor function (A~ fibres) in in vitro studies, although this is dose dependent (Markham & Faulds 1996). Its clinical efficacy appears to be quite similar to that of bupivacaine but it has a greater margin of safety. Ropivacaine is less cardiotoxic than bupivacaine. It has a similar onset time and duration of action.
Fentanyl is available in a combination product along with the butyrophenone tranquilliser fluanisone, and is marketed as 'Hypnorm'. It is used as a neuroleptanaesthetic/neuroleptanalgesic mixture in rats, rabbits, mice and guinea pigs. 4mg/ml with droperidol, 20mg/ml). It is used in dogs, cats, rabbits and laboratory rodents for premedication and sedation. It produces excellent analgesia of short duration (c. 30min). However, the sedation persists for considerably longer. Alfentanil This drug is only administered by intravenous injection, either as a bolus or more commonly by intravenous infusion.
Pain Management in Animals by Paul Flecknell, Avril Waterman-Pearson BVSc PhD FRCVS DVA DiplECVA